Number : W 81 XWH - 06 - 1 - 0673 TITLE : Erb 2 trafficking and signaling in human vestibular schwannomas PRINCIPAL

s/Presentations: Yue, WY, Woodson, E, Tryggvason, G, Clark, JJ, Hansen, MR. p75 is overexpressed in vestibular schwannomas and protects cells from apoptosis due to suppressed c-Jun N-terminal kinase (JNK) activity. American Association for Cancer Research, Washington DC, April 2010. Yue, WY, Clark, JJ, Domann, F, Hansen, MR. Persistent C-Jun N-terminal kinase activity contributes to the survival of human vestibular schwannoma cells by suppressing accumulation of mitochondrial superoxides. Association for Research in Otolaryngology, Anaheim, CA, February 2010. Gurgel, R, Clark, J, Provenzano, M, Hansen, M. Merlin phosphorylation on serine 518 by protein kinase A contributes to spiral ganglion and sciatic nerve Schwann cell proliferation following denervation. Association for Research in Otolaryngology, Baltimore, Maryland, February 2009. Cho, C-H, Xu, N, Han, GC, Green, S, Hansen, M. c-Jun N-terminal kinase is required for neurite growth in dissociated spiral ganglion neurons. Association for Research in Otolaryngology, Baltimore, Maryland, February 2009. Hansen, MR, Clark, JJ, Gantz, BJ, Goswami, PC. Effects of ErbB2 signaling on the response of vestibular schwannoma cells to γ-irradiation. Triologic Society, Orlando, Florida, May 2008— Fowler Award for Best Basic Science Thesis. Woodson, EA, Clark, JJ, Xu, N, Provenzano, MJ, Hansen, MR. Constitutive ERK and PI3-K activity each promote proliferation in vestibular schwannoma cells while constitutive JNK activity and p75NTR signaling protect against apoptosis. Association for Research in Otolaryngology, Phoenix, Arizona, February 2008. Clark, JJ, Brown, KD, Gantz, BJ, Hansen MR. Contribution of ErbB2 signaling to vestibular schwannoma cell proliferation and radiosensitivity. 5th International Conference on Vestibular Schwannomas and Other CPA Lesions, Barcelona, Spain, June 2007 Brown, KD, Clark, J, Hansen MR. Differential lipid raft localization of ErbB2 in vestibular schwannoma cells and Schwann cells. Combined Sections Meeting, Triologic Society, Marco Island, Florida, February 2007. Brown, KD, Clark, J, Hansen MR. Differential lipid raft localization of ErbB2 in vestibular schwannoma cells and Schwann cells. Association for Research in Otolaryngology, Denver, Colorado, February 2007.